CALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium
نویسندگان
چکیده
Jitka A. I. Virag,* Ethan J. Anderson,* Susan D. Kent, Harrison D. Blanton, Tracy L. Johnson, Fatiha Moukdar, Jonathan H. DeAntonio, Kathleen Thayne, Jian M. Ding, and Robert M. Lust Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina; and Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina
منابع مشابه
Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium.
We have previously shown that myocardial infarct size in nonreperfused hearts of mice with a functional deletion of the circadian rhythm gene mPer2 (mPer2-M) was reduced by 43%. We hypothesized that acute ischemia-reperfusion injury (I/R = 30 min I/2 h R) would also be reduced in these mice and that ischemic preconditioning (IPC) (3 × 5 min cycles) before I/R, which enhances protection in wild-...
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